Sebastian Demkowicz, Ph.D., D.Sc. Eng.
The scientific interests and the subject of research are focused on medicinal chemistry, including the development of new, original methods for the synthesis of organic compounds used in medicine and the investigation of the organic reaction mechanisms. The current research work is connected with design (using molecular modeling techniques), synthesis, and biological evaluation of new, potential chemotherapeutic agents (the inhibitors of enzymes of the estrogen biosynthesis, including aromatase, steroid sulfatase, 17β-hydroxysteroid dehydrogenase, or estrogen receptors) applicable in modern hormone-dependent cancer therapy. The research is interdisciplinary and combines the experiences of a number of (domestic and foreign) research groups in the field of molecular modeling, QSAR analysis, chemical synthesis, and biological research. Another direction in research is the application of mechanochemistry techniques in the development of new, efficient, and environmentally friendly methods for the synthesis of organic compounds ("green chemistry" approach).
Selected publications:
- Arthur-Baidoo E., Falkiewicz K., Chomicz-Mańka L., Czaja A., Demkowicz S., Biernacki K., Kozak W., Rak J., Denifl S.: Electron-Induced Decomposition of Uracil-5-yl O-(N,N-dimethylsulfamate): Role of Methylation in Molecular Stability, Int. J. Mol. Sci., 2021, 22, 2344.
- Ciupak O., Daśko M., Biernacki K., Rachoń J., Masłyk M., Kubiński K., Martyna A., Demkowicz S.: New potent steroid sulphatase inhibitors based on 6-(1-phenyl-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives, J. Enzyme Inhib. Med. Chem., 2021, 36(1), 238–247.
- Biernacki K., Daśko M., Ciupak O., Kubiński K., Rachoń J., Demkowicz S.: Novel 1,2,4-Oxadiazole Derivatives in Drug Discovery, Pharmaceuticals, 2020, 13(6), 111.
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