Sławomir Makowiec, Ph.D., D.Sc.

The main topics of the research concern the search and synthesis of compounds with anticancer properties, among them the most promising are design, development of synthesis methods and obtaining in quantities for biological research: 3,6-substituted carbazole derivatives as well as 2,3,4,9-tetrahydro-1H-carbazole. These compounds show antitumor activity as a result of the inhibition of telomerases. This project is carried out in cooperation with the Department of Pharmaceutical Technology and Biochemistry. Another research thread carried out in cooperation with the International Centre for Cancer Vaccine Science is maintained in a similar trend. In which it is crucial to obtain small molecule inhibitors of the UPF1 pathway; overactive in human neoplastic cells which allow for immune escape of neoplasms. Independently, also in cooperation with the Department of Pharmaceutical Technology and Biochemistry, we work with 3,4-functionalized tetrahydroquinolinones, these type of compounds, depending on the substituents they have, can cause strong oxidative stress in cancer cells.
The second branch of research concerns the issues of nanostructures and energy storage methods. For this purpose, in cooperation with the Department of Energy Conversion and Storage and the Department of Metrology and Optoelectronics of the Faculty of Electronics, Telecommunications and Informatics, we produce modified phosphorene structures as an alternative to graphene systems used in nanotechnological electronic solutions. Whereas, in the field of energy storage problems, we design and synthesize molecules used as reversible red-ox systems in flow accumulators. This project is carried out in cooperation with the Department of Physical Chemistry.
The third topic of our research is in the field of classical organic chemistry and focuses on the search for methods of synthesizing small heterocyclic systems, with particular emphasis on methods using oxidative cyclization with the use of transition metal ions. The implementation of this research thread also entails the need to study the reaction mechanisms.
 

Selected publications:

  1. Szewczyk M., Punda P., Janikowska K., Makowiec S.: Design, synthesis, and molecular docking of new 5-HT reuptake inhibitors based on modified 1,2-dihydrocyclopenta[b]indol-3(4H)-one scaffold, J. Chem. Sci., 2019, 131(6), 45.
  2. Szewczyk M., Ryczkowska M., Makowiec S.: Transition-Metal-Promoted Oxidative Cyclization To Give 1,2,4-Trisubstituted Carbazole Scaffolds, Synthesis, 2019, 51(24), 4625–4634.
     

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