Faculty seminar "On 'the track' of reactive metabolites: enzymatic vs. electrochemical synthesis ..."
On January 25th, 2024 1.15 pm in Auditorium 1.4 a faculty seminar will take place. The presentation will be given by dr inż. Agnieszka Potęga.
The topic of the speech is “On “the track” of reactive metabolites: enzymatic vs. electrochemical synthesis of products of activation and detoxification metabolism of anticancer (bis)acridine derivatives”
A graduate of the Gdańsk University of Technology, Faculty of Chemistry, field in Biotechnology, specialization in Pharmaceutical biotechnology. She holds a PhD in chemical sciences. She studies the metabolism of xenobiotics using an interdisciplinary in electro-in vitro-in vivo-in silico approach. The research constituting the habilitation achievement and being the topic of the presentation allowed for obtaining comprehensive knowledge about the products of activation (including reactive metabolites) and detoxification (formed by coupling reactive products with reduced glutathione) metabolism of selected compounds belonging to different groups of anticancer acridine derivatives. In particular, the conditions for forming, detecting, and identifying reactive products generated by investigated compounds in an electrochemical system coupled with a mass spectrometer (EC/MS) were developed and optimized for the first time.
